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Actual Gynecology
and Obstetrics

Abstrakt

Lymphocyte subpopulations in patients with ovarian endometrioma and healthy women – pilot study (article in Czech)
Lukáš Prajka, Miroslava Čedíková, Anežka Procházková, Kateřina Kabíčková, Gabriela Miklovičová, Martina Grundmanová, Magdaléna Kunová, Jan Humplík, Jiří Bouda
Actual Gyn 2023, 15, 9-15
Publication date: 2023-02-09
Manuscript ID: 1523002
Počet zobrazení: 1816
Abstrakt

Endometriosis is an estrogen-dependent, inflammatory, systemic, and chronic disease, characterized by the presence of ectopically deposited endometrial glands and stroma outside the uterine cavity. The aim of our study was to compare basic anamnestic and laboratory data with a more detailed focus on lymphocyte subpopulations in women with ovarian endometrioma in comparison with healthy controls. The study group consisted of 20 women, 10 patients with endometriosis, and 10 healthy women. Basic anamnestic information was obtained from each woman - age, weight, height, body mass index (BMI), age of menarche, length of the menstrual cycle, and length of menstrual bleeding. The detailed representation of lymphocyte subpopulations (B-lymphocytes, T-lymphocytes - TH-lymphocytes, TC-lymphocytes, double negative T-lymphocytes, and NK cells) were evaluated from laboratory parameters. Women with ovarian endometrioma reported a more extended period of menstrual bleeding and a significantly lower number of TH-lymphocytes and activated T-lymphocytes compared to the control group.
Immune cells play with the highest probability an important role in the pathophysiology of endometriosis, but their specific role is still unknown. To reveal the role, we need detailed research on the cells.

Key words: endometriosis, lymphocytes, immunity