Open access
Peer reviewed journal

Actual Gynecology
and Obstetrics


Management of severe first trimester onset intrahepatic cholestasis of pregnancy - case report and review of literature (article in Slovak)
Marcela Ňachajová, Petra Turňová, Erik Kúdela, Zuzana Laučeková, Štefan Novysedlák, Kamil Biringer
Actual Gyn 2021, 13, 17-20
Publication date: 2021-02-25
Manuscript ID: 1321002
Počet zobrazení: 8147

Intrahepatic cholestasis of pregnancy represents the most common pregnancy related liver disease in pregnancy. We present the case of rare, first-trimester onset intrahepatal cholestasis with coincidence with primary biliary cholangoitis. The combination of two diseases caused severe bile acid elevation. We decided to add Rifampicin to therapy after failure of basic combination of ursodeoxycholic acid and S-adenyl methionin. We performed cesarean section in 30 weeks of pregnancy because of acute severe elevation of bile acids. Ursodeoxycholic acid was continued postpartum with normalization of bile acids.

Key words: intrahepatal cholestasis of pregnancy, primary biliary cholangoitis, ursodeoxycholic acid, S-adenyl methionin, Rifampicin