Open access Peer reviewed journalwww.actualgyn.com
Indole-3-carbinol is a phytochemical derived from cruciferous vegetables. After its consumption, in acidic enviroment of stomach, several oligomeric components with different biological activity are formed, including 3,3´-diindolylmethane. They are characterized by antiestrogen and antiproliferative activity. Studies have shown positive results in investigating the effect of indole-3-carbinol and its metabolite 3,3´-diindolylmethane in connection with various oncological diseases, in dysplastic lesions of the cervix, vulvar intraepithelial neoplasia, or breast cancer cells. By favorably influencing estrogen metabolism, glucose metabolism and reducing insulin resistance, it appears to be a promising complementary treatment for polycystic ovarian syndrome or other hormonal disorders. The use of indole-3-carbinol is considered safe, without the occurrence of serious side effects. The aim of the article was to summarize the current knowledge of the effect of indole-3-carbinol and its metabolites.